Study shows the progression of multiple sclerosis can be slowed

Multiple Sclerosis (MS) is difficult to diagnose, and, as yet, it has no cure. However, according to new research, it may be possible to slow its progression without some of the health risks associated with current treatments.

Share on PinterestNew research in mice shows a mechanism through which it is possible to slow MS.

MS is a chronic disease of the central nervous system (CNS) that disrupts nerve signals between the brain and the rest of the body.

While nearly 1 million people in the United States over the age of 18 years live with a diagnosis of MS, and 2.3 million people globally have the condition, its causes remain a mystery. Women are two to three times more likely than men to receive an MS diagnosis, and most people with MS are 20–50 years old.

The symptoms, which may come and go or worsen, include weakness, blurred vision, lack of coordination, imbalance, pain, memory lapses, mood changes, and — less commonly — paralysis, tremor, and blindness.

The flightiness of MS and the nonspecific nature of its symptoms make it difficult to diagnose, and there is currently no hope of a cure. However, there are certain drugs, commonly known as anti-B cell drugs, which help moderate attacks and delay the progression of disability.

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MS: Common herpesvirus variant raises risk

New research distinguishes between two similar variants of the human herpesvirus 6 and finds that one variant significantly increases the risk of developing Multiple Sclerosis (MS).

Share on PinterestScientists have linked the Epstein-Barr virus (depicted here) with MS.

MS is an autoimmune condition that affects around 400,000 people in the United States and 2.5 million people worldwide.

The condition affects the central nervous system, "tricking" the immune system into attacking the protective myelin sheath that surrounds the nerve cells.

The medical community has not yet identified the cause of MS. Many health professionals believe that genetic predisposition plays a role, with environmental factors such as smoking and viral infections potentially triggering MS risk genes.

Of all the viruses that may play a role in the development of MS, the Epstein-Barr virus (EBV) — which causes mononucleosis — has received the most attention from researchers.

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Why is my leg shaking?

Leg shaking can be a subtle annoyance or an intense experience that causes muscle tension and difficulty walking. Many issues, ranging from restless legs syndrome (RLS) to serious conditions such as dementia, can cause someone's leg to shake.

It is not possible to diagnose the cause of shaky legs based on symptoms alone. For this reason, people who experience leg shaking should speak to a doctor or healthcare provider.

Keep reading this article to learn about 10 possible causes of leg shaking.

Share on PinterestA tremor is a possible cause of leg shaking.

A tremor is an involuntary muscle contraction. The contraction is rhythmic, so a person might feel the muscle shaking or moving at predictable intervals.

A person with a leg tremor may notice their leg shaking while a muscle or group of muscles pulses or spasms out of control. The tremor may last for a few minutes, or it may be an ongoing problem.

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Everything you need to know about syringomyelia

Syringomyelia is a rare disorder in which a fluid filled cyst forms in the spinal cord. Cerebrospinal fluid surrounds and protects the brain and spinal cord. Syringomyelia happens when this fluid collects within the spinal cord and forms a cyst.

The cyst is called a syrinx. Over time, the syrinx gets bigger and can damage the spinal cord and surrounding nerve fibers.

In this article, learn about the causes and symptoms of syringomyelia, as well as the treatment options and the outlook for a person with this disorder.

Causes and risk factors


Syringomyelia may cause pain in the shoulders and neck

In most cases, people have a type of syringomyelia called congenital syringomyelia. An abnormality called a Chiari malformation, which can happen when the fetus is developing in the womb, is responsible for this form of the condition.

In people with a Chiari malformation, the brain tissue extends further than normal from the back of the head into the upper part of the spinal cord. This structural abnormality affects the flow of cerebrospinal fluid and may cause a syrinx to form.

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Does sunlight change our gut microbiome?

Scientists show that ultraviolet (UV) light exposure leads to changes in the gut microbiome, but only in volunteers who were deficient in vitamin D.

Share on PinterestCan sunlight affect our gut microbiomes?

There is plenty of evidence that links vitamin D, the sunshine vitamin, to health outcomes.

Living at higher latitudes, which means less exposure to UV light and a greater chance of being vitamin D deficient, carries a higher risk of developing diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD).

Research into the gut microbiome indicates that our microbial passengers may play a significant part in these conditions.

But what links vitamin D to our intestinal microbiota?

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What causes left sided facial numbness?

Left sided facial numbness is a symptom that involves a decreased or complete loss of sensation in this area of the body. It can be the result of several different conditions, including a stroke or migraine.

Numbness on the left side of the face can present as a loss of feeling, but it may also produce a tingling or burning sensation. It is also possible for the facial muscles to become paralyzed and unable to move, which can cause one side of the face to droop.

Some of the causes of left sided facial numbness are easily treatable, but others are more serious. In this article, we discuss some possible causes of this symptom and their treatment options.

Strokes and transient ischemic attacks


There are multiple causes of left sided facial numbness.

A stroke occurs when there is a disruption in the blood flow to the brain. It can result from a blood vessel in the brain bursting or the blockage of a blood vessel carrying blood to the brain.

Sudden numbness of the face is one of the warning signs of a stroke. It can occur on the left or right side and rarely affects the whole face. It is essential to seek immediate medical help for a stroke.

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MS: High-strength MRI may predict disease progression

Researchers used a powerful MRI scanner to monitor people with Multiple Sclerosis and found a link between the total volume of cortical lesions and neurological disability.


Researchers were able to detect previously unidentified MS lesions in the brain using a powerful MRI scanner.

Their study reveals that the development of lesions in the brain's cortical gray matter may be a predictor of neurological disability for people with multiple sclerosis (MS).

The scientists used a high-strength MRI to detect lesions and evaluate the progression of the disease. They published their findings in the journal Radiology.

To track the MS participants for the study, the research team used a 7-Tesla (7T) MRI scanner. The magnetic field strength of this scanner is more than twice as powerful as more everyday versions.

The 7T machine is also more sensitive to cortical lesions and, in this instance, it was able to detect many lesions that researchers have not been able to see in previous studies.

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Study finds that many people diagnosed with MS do not have the condition

Researchers found that nearly 1 in 5 people who had received a diagnosis of Multiple Sclerosis had other unrelated conditions.


Some conditions, such as stroke or migraine, have similar symptoms to MS.

Multiple sclerosis (MS) is a widespread disabling neurological condition in which the immune system attacks and destroys the fatty tissue that surrounds the nerves. This leads to nerve damage, which affects communication between the nerves and the brain.

People with MS may experience symptoms, including numbness or weakness in the limbs, tremors, and lack of coordination. However, some of the symptoms have similarities to other debilitating conditions, including stroke and migraine.

MS and stroke are very different conditions, but they both harm the brain. Some of the symptoms they share include attention issues, dizziness, numbness in the limbs, slurring, visual impairment, and difficulty in walking.

MS and migraine attacks also have some symptoms in common, including dizziness and vision impairment. A recent study pooled data on people who had received a wrong diagnosis of MS and found that 72 of the 110 patients had other conditions, including migraine and fibromyalgia.

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What to know about neuralgia

Neuralgia refers to severe, shooting pain that occurs due to a damaged or irritated nerve. Neuralgia can affect any part of the body, causing mild to severe pain. Certain medications and surgical procedures can effectively treat neuralgia.

Severe neuralgia can interfere with a person's ability to perform everyday tasks and may impact their quality of life.

Neuralgia has many possible causes, including:

infections, such as shingles, Lyme disease, or HIVpressure on nerves from bones, blood vessels, or tumorsother medical conditions, such as kidney disease or diabetesaging

This article covers the different types of neuralgia, their symptoms, and the treatment options available.

Types of neuralgia

Healthcare professionals divide neuralgia into categories depending on the areas of the body it affects. The following are some common types of neuralgia:

Trigeminal neuralgia


TN can cause shooting pain in the face.

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What to know about optic neuritis and MS

Multiple Sclerosis can damage the nerves in the eye, leading to optic neuritis. symptoms of optic neuritis include vision problems, painful eyes, and temporary vision loss.

Multiple sclerosis (MS) can cause inflammation and damage to the myelin sheath in the optic nerve. This damage is called optic neuritis. Although the symptoms of optic neuritis tend to subside over time, some people may also benefit from various treatments.

Visual disturbances are among the most common symptom that people with MS have. One study found that optic neuritis is the first sign of MS in about 15–20% of people with the condition.

In this article, we look at the link between MS and optic neuritis, along with its symptoms, causes, treatments, and diagnosis.

What is the link?


MS can cause problems with vision.

MS is a chronic condition wherein the immune system mistakenly attacks the protective myelin sheath that surrounds the nerve cells. These attacks damage these cells, causing inflammation and permanent scarring in the brain, spinal cord, and other nerves.

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How childhood viral infections may later drive multiple sclerosis

Childhood viral infections that reach the brain may prime it for the development of autoimmune conditions, such as Multiple Sclerosis, later in life — this is what a recent study that scientists conducted in mice seems to suggest.


Could viral infections that occur during childhood 'pave the way' for MS later in life?

Recent research has shown that multiple sclerosis (MS) is the most common neurological autoimmune condition among young adults worldwide, with 2,221,188 prevalent cases of MS in 2016 alone.

This condition can cause problems with movement, balance, coordination, and even vision, alongside fatigue and other symptoms.

Despite the fact that MS can be debilitating, and that it affects such a large number of people worldwide, scientists are still unsure what causes it.

Now, a team of researchers from the University of Geneva (UNIGE) and the Geneva University Hospitals in Switzerland are proposing a new theory that viral infections during childhood could reach the brain and render the development of an autoimmune condition more likely later in life.

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What causes numbness in the thigh?

Many factors can cause numbness in the thigh. These include keeping the legs crossed for too long, wearing tight clothing, Multiple Sclerosis (MS), and lupus. Treatment options depend on what is causing the numbness.

From conditions affecting blood flow to damage to the nerves themselves, there are many potential causes of numbness in the thigh. Depending on the cause, there are also many treatments available.

This article will cover some common underlying causes of numbness in one or both thighs. We also discuss treatment options.

Meralgia paresthetica


There are a number of causes for numbness in the thigh.

Meralgia paresthetica is a neurological condition that causes numbness or tingling on the outer and front aspect of the thigh.

According to an article in the journal Pain Medicine, the condition is most common in people aged 30–40 years.

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What are the best exercises for MS?

Exercise has a range of benefits for people with Multiple Sclerosis. It can, for example, help improve strength and mobility and boost mental well-being.

In previous years, doctors recommended that people with multiple sclerosis (MS) avoid too much physical activity, believing that it could make fatigue and other symptoms worse.

However, research has since revealed that exercise can, in fact, improve MS symptoms over time.

In this article, we discuss the best exercises for MS, their benefits, and tips for staying safe while exercising.

How can exercise help with MS?


Regular exercise can help people with MS improve their mobility, muscle movements, and overall quality of life.

MS is a progressive inflammatory disease that damages the myelin sheaths that coat nerve cells. An estimated 2.3 million people worldwide have MS. The symptoms come and go over time and can include numbness or tingling in the limbs, muscle weakness, and fatigue.

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How do ancient viruses cause MS and other neurological diseases?

Ancient viruses have left behind traces in our DNA. Researchers believe these contribute to neurological conditions. Could inhibiting our viral passengers pave the way for future treatments?


What links neurological conditions and ancient viruses?

Transposable elements, which scientists also call transposons or jumping genes, are stretches of DNA that harbor the ability to move around our genome.

Scientists can trace back one type of transposon — human endogenous retroviruses (HERVs) — to ancient retroviruses that inserted themselves into the human genome millions of years ago. HERVs make up about 8% of our DNA.

Some HERVs hold crucial functions during processes such as embryonic development. But most HERVs lie dormant, silenced by DNA modifications.

Yet, in a recent review article in Frontiers in Genetics, researchers from Heinrich Heine University in Dusseldorf, Germany, detail how some HERVs may be reactivated and wreak havoc in our brain and central nervous system.

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What to know about MS fatigue

Fatigue is one of the most common and disabling symptoms of Multiple Sclerosis (MS). It is often the most significant symptom that people with few other symptoms experience.

Some lifestyle changes, healthful habits, and medications can help people manage MS fatigue.

In this article, we discuss the symptoms, causes, and treatment of MS fatigue.

symptoms


Around 90% of people diagnosed with MS experience fatigue.

Fatigue affects as many as 90% of people with MS. It is often one of the first symptoms to develop, and it may begin years before the diagnosis of MS.

People who have fatigue feel constantly exhausted, usually regardless of their activity levels and hours of sleep. They may find it difficult to do everyday tasks, such as dressing, bathing, and preparing meals.

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Vaccinations do not raise risk of multiple sclerosis

A large study has concluded that vaccinations are not a risk factor for Multiple Sclerosis. Instead, the findings reveal a consistent link between higher vaccination rates and a lower likelihood of developing the disabling condition.


There is no evidence that vaccinations increase the likelihood of MS.

Researchers at the Technical University of Munich (TUM) in Germany studied data on more than 200,000 people who were representative of the general population.

The data came from the Bavarian Association of Statutory Health Insurance Physicians records covering the period 2005–2017.

The records held people's vaccination history and diagnosed conditions and included data on 12,262 people with a diagnosis of multiple sclerosis (MS).

The dataset included dates of vaccinations for chickenpox, measles, mumps, rubella, influenza, meningococci, pneumococci, human papillomavirus (HPV), tick-borne encephalitis (TBE), and hepatitis A and B.

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Rejuvenating brain stem cells may hold key to future MS treatments

Scientists have found a way to make older brain stem cells in rats more youthful. The discovery could lead to improved treatments for aging-related diseases that degrade the brain and nervous system.


Researchers managed to rejuvenate stem cells, inching closer to more effective treatments for MS.

The research concerns oligodendrocyte progenitor cells (OPCs), which are a type of stem cell, or immature cell. OPCs are essential for the healthy functioning of the brain and the rest of the central nervous system.

OPCs mature, or differentiate, into oligodendrocytes, which are the cells that produce the myelin sheath that surrounds nerve fibers and preserves the electrical signals that they carry.

Destruction of myelin is a distinguishing feature of Multiple Sclerosis (MS), and aging-related changes to OPCs contribute to the process. Aging can also reduce OPC function in healthy individuals.

Researchers at the University of Cambridge in the United Kingdom found that increasing stiffness in the aging brain impairs the function of OPCs.

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What causes numbness and tingling?

Temporary numbness and tingling can occur after spending too much time sitting cross-legged, or with a head resting on a crooked arm.

But long term, severe, or disabling numbness and tingling is usually a sign of neurological conditions or nerve damage.

This article focuses on common causes and treatments for numbness and tingling, including multiple sclerosis (MS).

Causes in different parts of the body


Numbness and tingling may occur after resting the head on a crooked arm.

Numbness (lost, reduced, or altered sensation) and tingling (an odd prickling sensation) are types of temporary paresthesia.

These sensations commonly occur after sitting or standing in a particular position or even wearing tight clothing for too long. This puts pressure on nerves and blood vessels, reducing sensation.

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MS: Paleo diet may reduce fatigue by improving cholesterol

New research investigates the effect of following a Wahls paleo diet on fatigue in Multiple Sclerosis (MS).


A diet rich in vegetables, fruit, meat, and fish may improve fatigue in MS.

According to some estimates, at least two-thirds of people with MS experience debilitating fatigue as part of their condition.

There are many possible explanations for fatigue in MS.

For example, exhaustion can result from the pathobiological processes associated with this condition, such as inflammation of the nervous system or demyelination.

It may also result from psychological conditions that often accompany MS, such as depression and stress.

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Aubagio (teriflunomide)

FDA warnings

This drug has boxed warnings. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.

Severe liver damage. Aubagio can cause severe liver problems, including liver failure. Taking Aubagio with other drugs that can affect your liver can increase the amount of Aubagio in your body. This can damage your liver. One of these drugs is Arava (leflunomide), which is prescribed to treat rheumatoid arthritis. Your doctor will give you blood tests before and while you take Aubagio to check your liver.Risk of birth defects. If you're pregnant, you shouldn't take Aubagio because it may cause major birth defects. If you might become pregnant and aren't using reliable birth control, you shouldn't take Aubagio. If you become pregnant while on Aubagio, stop taking it and tell your doctor right away.

What is Aubagio?

Aubagio is a brand-name prescription medication. It's used to treat relapsing forms of multiple sclerosis (MS) in adults. MS is an illness in which your immune system attacks your central nervous system.

Aubagio contains the drug Teriflunomide, which is a pyrimidine synthesis inhibitor. Drugs in this class help prevent immune cells from quickly multiplying. This action helps decrease inflammation (swelling).

Aubagio comes as a tablet that you swallow. The drug is available in two strengths: 7 mg and 14 mg.

Aubagio was compared to a placebo (no treatment) in four clinical trials. People who took Aubagio had:

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