An international collaboration led by scientists at Yale has cracked a tough nut in Multiple Sclerosis: Where are all the genes?
Previous work by the International Multiple Sclerosis Genetics Consortium (IMSGC) has identified 233 genetic risk variants. However, these only account for about 20% of overall disease risk, with the remaining genetic culprits proving elusive. To find them, the IMSGC pooled more than 68,000 MS patients and control subjects from Australia, ten European countries, and the United States. This time, researchers looked for rare variants that directly damage gene sequence. They found four new genes that act independently as risk factors for the disabling autoimmune disorder, they report Oct. 18 in the journal Cell.
"We simply would not have found them by continuing to look at common genetic variants; we had to look for rarer events, which means looking at many, many more people," said Yale's Chris Cotsapas, associate professor of neurology and genetics and corresponding author of the study. "These variants explain an extra 5% of risk."
Previous theories have held that combinations of common variants act in concert to explain more risk than each one alone, or that some families carry private mutations that cause disease only in those individuals.
"We've looked in thousands of people to test those theories, and they just aren't true," Cotsapas said. "The data don't bear them out."
The novel variants identified code for proteins, making them easier to study, and offer researchers promising new ways to study MS, researchers said.
The IMSGC was founded in 2003 to study the genetic basis of MS. It now comprises over 200 laboratories from across the world and has identified almost 250 separate genetic risk factors for the disease. More information can be found at the International Multiple Sclerosis Consortium website: http://imsgc.net/
Journal Reference:International Multiple Sclerosis Genetics Consortium. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. Cell, 2018; DOI: 10.1016/j.cell.2018.09.049
Cite This Page:
Yale University. "MS genes formerly missing-in-action have been found." ScienceDaily. ScienceDaily, 18 October 2018. <www.sciencedaily.com/releases/2018/10/181018141041.htm>.
Yale University. (2018, October 18). MS genes formerly missing-in-action have been found. ScienceDaily. Retrieved September 18, 2019 from www.sciencedaily.com/releases/2018/10/181018141041.htm
Yale University. "MS genes formerly missing-in-action have been found." ScienceDaily. www.sciencedaily.com/releases/2018/10/181018141041.htm (accessed September 18, 2019).
May 17, 2016 — In a recent study, children with Multiple Sclerosis had differences in the abundance of specific gut bacteria than children without the disease. Certain types of bacteria were either more or less ... read more
Sep. 19, 2014 — Positive new data have been released on a drug candidate, RPC1063, for relapsing Multiple Sclerosis. According to the results from a six-month Phase 2 study of 258 Multiple Sclerosis patients, the ... read more