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Read more about efforts to understand tissue damage in MS
Investigating whether debris from damage caused by the immune attack causes further damage to nerve cells during the course of MS.Exploring how alterations in the myelin coating after immune attacks affect the health and behavior of nerve fibers.Identifying processes that contribute to the loss of myelin and ways to restore myelin to protect nerves and their function.Seeking ways to diagnose MS earlier to enable earliest treatment as the best insurance against future damage.Developing high-powered imaging as a window to seeing how MS causes damage and as a tool for tracking the success of treatments.Past Success
The MS Lesion Project was a major collaboration of investigators worldwide who sought to understand the damage MS does to the nervous system and ultimately improve its treatment. This large-scale project was funded through the Society’s Promise: 2010 Initiative.
investigators sought to understand patterns of MS damage in lesions—spots of brain tissue where myelin has been stripped from nerve fibers. Claudia F. Lucchinetti, MD, with collaborators in the U.S., Germany and Austria, launched the most extensive attempt ever to map and understand the meaning of MS damage in the brain. They amassed an unprecedented collection of tissue samples from more than 1,000 people with MS, obtained from brain biopsies (a rare procedure) or autopsies. By identifying four distinct kinds of lesion patterns, the collaborators:
We are making progress
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