By accepting you will be accessing a service provided by a third-party external to

What to Know About MS and the JC Virus

This common virus is harmless to most of the population. But it can have serious effects for those with Multiple Sclerosis.

What is the JC virus?
The John Cunningham virus, known more commonly as the JC virus, is a very common virus in the United States. According to the World Journal of Neurosciences, between 70 and 90 percent of people in the world have the virus. The average person carrying the JC virus will never know and is unlikely to experience any side effects.
However, that’s not the case for a small percentage of individuals with multiple sclerosis (MS). The JC virus can be activated when a person’s immune system is compromised because of disease or immunosuppressive medication.
The virus can then be carried into the brain. It infects the white matter of the brain and attacks the cells responsible for making myelin, the protective coating that covers and protects nerve cells. This infection is called progressive multifocal leukoencephalopathy (PML). PML can be disabling, even fatal.

The role of immune-suppressing drugs

The JC virus often attacks when a person’s immune system is at its weakest. A weakened immune system can no longer fight off invading viruses. It’s the perfect opportunity for the JC virus to awaken, cross the blood-brain barrier, and begin attacking the brain. People with MS are at an increased risk for PML because their immune system is often compromised as a result of the condition.
Further compounding the problem, several medications used to treat the symptoms of MS can also compromise the immune system. Immunosuppressant medications can increase the likelihood that a person with MS will develop PML after exposure to the JC virus. These immunosuppressant medications may include:
azathioprine (Azasan, Imuran)cyclophosphamidedimethyl fumarate (Tecfidera)methotrexatemitoxantrone (Novantrone)mycophenolate mofetil (CellCept)corticosteroids
Continue reading by clicking here

This Article is Provided by:  #MSViewsandNews
Visit our MS Learning Channel on YouTube:
(Originally posted by Stuart)
How to Find the Right MS Treatment
New insights into how immune system and inflammati...


No comments made yet. Be the first to submit a comment
Already Registered? Login Here
Sunday, 31 May 2020

Captcha Image RSS Statement

Most of the information found on this website comes from RSS Feeds. It is an automated task that provides the information to you. We try to limit items that are duplicates, but with many feeds this can be difficult. Since the owner of this website also has MS and is legally blind this service was necessary to keep the website running with as much automation as possible. Volunteers help from time to time but many have disabilities themselves. We thank you for visiting us and hope that MSC can be of service to you and your loved ones.