Assuming disease is required, the following results were found.

  • Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 - Science

    I IFN activity has been linked to several human pathologies, but evidence implicating this cytokine response directly in disease has been limited. Here, Duncan et al. identified a homozygous missense mutation in STAT2 in siblings with severe early-onset...

    https://mschristian.org/index.php/blog/severe-type-i-interferonopathy-and-unrestrained-interferon-signaling-due-to-a-homozygous-germline-mutation-in-stat2-science
  • Rethinking neurodegenerative disease treatment: Target multiple pathological proteins

    Nearly all major neurodegenerative diseases -- from Alzheimer's to Parkinson's -- are defined and diagnosed by the presence of one of four proteins that have gone rogue: tau, amyloid-beta (Aβ), alpha-synuclein (α-syn), or TDP-43. As such,...

    https://mschristian.org/index.php/blog/rethinking-neurodegenerative-disease-treatment-target-multiple-pathological-proteins
  • Coronavirus Outbreak: Daily Updates

    The outbreak, initially identified in China, is continuing to grow.The disease is called COVID-19. It’s caused by an infection with the new coronavirus, SARS-CoV-2, which is one of multiple coronaviruses that can be transmitted to humans.Other examples...

    https://mschristian.org/index.php/coronavirus-outbreak-daily-updates
  • Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 - Science

    I IFN activity has been linked to several human pathologies, but evidence implicating this cytokine response directly in disease has been limited. Here, Duncan et al. identified a homozygous missense mutation in STAT2 in siblings with severe early-onset...

    https://mschristian.org/index.php/articles/2-uncategorised/9542-severe-type-i-interferonopathy-and-unrestrained-interferon-signaling-due-to-a-homozygous-germline-mutation-in-stat2-science
  • Rethinking neurodegenerative disease treatment: Target multiple pathological proteins

    Nearly all major neurodegenerative diseases -- from Alzheimer's to Parkinson's -- are defined and diagnosed by the presence of one of four proteins that have gone rogue: tau, amyloid-beta (Aβ), alpha-synuclein (α-syn), or TDP-43. As such,...

    https://mschristian.org/index.php/articles/2-uncategorised/4250-rethinking-neurodegenerative-disease-treatment-target-multiple-pathological-proteins
  • Novartis receives positive CHMP opinion for Mayzent® (siponimod) for the treatment of adult patients with active secondary progressive multiple sclerosis (SPMS) | Small Molecules | News Channels - PipelineReview.com

    in a broad SPMS patient population (EDSS score 3.0 to 6.5 at baseline), showing Mayzent significantly reduced the risk of disease progression, including physical disability and cognitive decline[2]Up to 80% of patients with relapsing remitting multiple...

    https://mschristian.org/index.php/blog/novartis-receives-positive-chmp-opinion-for-mayzent-siponimod-for-the-treatment-of-adult-patients-with-active-secondary-progressive-multiple-sclerosis-spms-small-molecules-news-channels-pipelinereview-com
  • CorTechs Labs Enters Phase 2 of $1.15 Million NIH Grant to Automate the Diagnosis and Prediction of Alzheimer's Disease - Business Wire

    Labs Inc. announced today that it has officially entered the second phase of its project titled, Diagnosis of Alzheimer’s disease and prediction of clinical progression using an automated PET image analysis tool. This project, funded by a $1.15 million,...

    https://mschristian.org/index.php/blog/cortechs-labs-enters-phase-2-of-1-15-million-nih-grant-to-automate-the-diagnosis-and-prediction-of-alzheimer-s-disease-business-wire
  • Rare Shrew-Borne Illness Tied to Fatal Encephalitis

    Additional evidence emerged in Germany that Borna disease virus, which resides in shrews, was associated with fatal encephalitis in people there. Analysis of brain tissue in eight cases of encephalitis believed to have a viral origin -- going back as...

    https://mschristian.org/index.php/blog/rare-shrew-borne-illness-tied-to-fatal-encephalitis
  • Novartis receives positive CHMP opinion for Mayzent® (siponimod) for the treatment of adult patients with active secondary progressive multiple sclerosis (SPMS) | Small Molecules | News Channels - PipelineReview.com

    in a broad SPMS patient population (EDSS score 3.0 to 6.5 at baseline), showing Mayzent significantly reduced the risk of disease progression, including physical disability and cognitive decline[2] Up to 80% of patients with relapsing remitting multiple...

    https://mschristian.org/index.php/articles/2-uncategorised/9270-novartis-receives-positive-chmp-opinion-for-mayzent-siponimod-for-the-treatment-of-adult-patients-with-active-secondary-progressive-multiple-sclerosis-spms-small-molecules-news-channels-pipelinereview-com
  • Forgotten immune cells protective in mouse model of multiple sclerosis

    A seldom-studied class of immune cells may reduce the friendly fire that drives autoimmune disease, according to a new study by researchers at the Stanford University School of Medicine. Stimulating these protective cells could lead to new therapies...

    https://mschristian.org/index.php/blog/forgotten-immune-cells-protective-in-mouse-model-of-multiple-sclerosis
  • New treatment shows promise to reverse celiac disease

    developed at Northwestern Medicine show it is possible to induce immune tolerance to gluten in individuals with celiac disease. The findings may pave the way for treated celiac patients to eventually tolerate gluten in their diet. After treatment with...

    https://mschristian.org/index.php/articles/2-uncategorised/8995-new-treatment-shows-promise-to-reverse-celiac-disease
  • CorTechs Labs Enters Phase 2 of $1.15 Million NIH Grant to Automate the Diagnosis and Prediction of Alzheimer's Disease - Business Wire

    Labs Inc. announced today that it has officially entered the second phase of its project titled, Diagnosis of Alzheimer’s disease and prediction of clinical progression using an automated PET image analysis tool. This project, funded by a $1.15 million,...

    https://mschristian.org/index.php/articles/2-uncategorised/9191-cortechs-labs-enters-phase-2-of-1-15-million-nih-grant-to-automate-the-diagnosis-and-prediction-of-alzheimer-s-disease-business-wire
  • How the gut influences neurologic disease

    Researchers are identifying the key players involved in the gut-brain connection and their role in disease progression Date: Source: Brigham and Women's Hospital Summary: A study sheds new light on the connection between the gut and the brain,...

    https://mschristian.org/index.php/articles/2-uncategorised/4107-how-the-gut-influences-neurologic-disease
  • Stem cell transplant reverses disabling MS-like disease - Medical Xpress

    Credit: CC0 Public Domain A stem cell transplant reversed a debilitating neurological disease that causes half of the patients to go blind and lose the ability to walk five years after diagnosis. Most of the patients stayed better five years after the...

    https://mschristian.org/index.php/blog/stem-cell-transplant-reverses-disabling-ms-like-disease-medical-xpress
  • Stroke drug may also prevent Alzheimer's disease

    have discovered that a drug currently being developed to treat stroke patients could also prevent Alzheimer's disease. The study shows that the genetically engineered protein 3K3A-APC protects the brains of mice with Alzheimer's-like symptoms, reducing...

    https://mschristian.org/index.php/blog/stroke-drug-may-also-prevent-alzheimer-s-disease
  • Economic Factors Amplify Burden of Disease for Patients With Multiple Sclerosis

    issues differ across countries and healthcare systems, a universal concern is that multiple sclerosis (MS) is a costly disease that exerts a significant burden on patients, families, and society as a whole. Speaking at the ECTRIMS 2019 Congress in...

    https://mschristian.org/index.php/blog/economic-factors-amplify-burden-of-disease-for-patients-with-multiple-sclerosis
  • What Happened With a Once-Promising Alzheimer's Drug

    Lanabecestat, a once-promising investigational drug for Alzheimer's disease, did not improve cognition, according to two late-stage clinical trials that had been stopped for futility. Despite evidence that amyloid levels were lower, daily lanabecestat...

    https://mschristian.org/index.php/blog/what-happened-with-a-once-promising-alzheimer-s-drug
  • Stroke drug may also prevent Alzheimer's disease

    Researchers have discovered that a drug currently being developed to treat stroke patients could also prevent Alzheimer's disease. The study shows that the genetically engineered protein 3K3A-APC protects the brains of mice with Alzheimer's-like...

    https://mschristian.org/index.php/articles/2-uncategorised/5160-stroke-drug-may-also-prevent-alzheimer-s-disease
  • Disability in multiple sclerosis A reference for patients and clinicians

    outcomes in multiple sclerosis (MS) that would enable patients to rank their disability relative to others' with similar disease duration and to develop a cost-effective research tool for comparing MS severity across patient populations and time...

    https://mschristian.org/index.php/blog/disability-in-multiple-sclerosis-a-reference-for-patients-and-clinicians
  • Stem cell transplant reverses disabling MS-like disease - Medical Xpress

    Credit: CC0 Public Domain A stem cell transplant reversed a debilitating neurological disease that causes half of the patients to go blind and lose the ability to walk five years after diagnosis. Most of the patients stayed better five years after the...

    https://mschristian.org/index.php/articles/2-uncategorised/8856-stem-cell-transplant-reverses-disabling-ms-like-disease-medical-xpress

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