Assuming ratio is required, the following results were found.

  • Blood neurofilament light chain as a biomarker of MS disease activity and treatment response

    NfL levels were associated (estimate [95% confidence interval]) with an increased number of new or enlarging T2 lesions (ratio of mean: 2.64 [1.51–4.60]; p = 0.0006), relapses (rate ratio: 2.53 [1.67–3.83]; p...

    https://mschristian.org/index.php/blog/blood-neurofilament-light-chain-as-a-biomarker-of-ms-disease-activity-and-treatment-response
  • Could medical marijuana help older people with their ailments?

    people with an average age of 81 who were enrolled in New York State's Medical Marijuana Program. Participants took various ratios of tetrahydrocannabinol (THC) to cannabidiol (CBD), the main active chemicals in medical marijuana, for an average of four...

    https://mschristian.org/index.php/blog/could-medical-marijuana-help-older-people-with-their-ailments
  • Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 - Science

    Type I interferons (including IFNα/β) areantiviral cytokines with pleiotropic functions in the regulation of cellular proliferation, death, and activation. Reflecting their medical importance, type I IFNs have been shown to be essential to antiviral...

    https://mschristian.org/index.php/blog/severe-type-i-interferonopathy-and-unrestrained-interferon-signaling-due-to-a-homozygous-germline-mutation-in-stat2-science
  • Anesthesia Technique Flops in Large Breast Cancer Trial

    remained similar for both, at 28% with the regional technique and 27% with general anesthesia (overall interim-adjusted odds ratio [OR] 1.00, 95% CI 0.85-1.17, P=0.99). The frequency of neuropathic pain in the breast area was also the same for both...

    https://mschristian.org/index.php/blog/anesthesia-technique-flops-in-large-breast-cancer-trial
  • Siponimod Delays Time to Wheelchair in Secondary Progressive MS - Neurology Times

    EDSS of 6.5 progressed to a score of ≥7, compared to 26.1% of placebo patients, equating to a risk reduction of 36% (hazard ratio [HR], 0.64; 95% CI, 0.41–1.0; P = .0483). In the multistate model, a similar reduction of 21% risk of transitioning from...

    https://mschristian.org/index.php/blog/siponimod-delays-time-to-wheelchair-in-secondary-progressive-ms-neurology-times
  • MS Risk Nearly Doubles 15 Years Following Teen Concussion - Medscape

    study presented at ECTRIMS in 2017 showedadolescents with one concussion diagnosis were at elevated risk to develop MS (odds ratio [OR], 1.22; 95% confidence interval [CI], 1.05 - 1.42; P = .008). The study, published the same year in Annals of...

    https://mschristian.org/index.php/blog/ms-risk-nearly-doubles-15-years-following-teen-concussion-medscape
  • Genentech’s Satralizumab Significantly Reduced Relapse Risk in Second Positive Phase III Study for Neuromyelitis Optica Spectrum Disorder

    reduction in the risk of relapses compared to placebo in the overall population, representative of NMOSD patients (Hazard Ratio [HR]=0.45, 95% Confidence Interval [CI]: 0.23-0.89; p=0.0184). In the large (~67%) subgroup of patients seropositive for...

    https://mschristian.org/index.php/blog/genentech-s-satralizumab-significantly-reduced-relapse-risk-in-second-positive-phase-iii-study-for-neuromyelitis-optica-spectrum-disorder
  • Biogen Strengthens MS & SMA Portfolio as Competition Lurks - Yahoo Finance

    in the United States and internationally. It has now become the standard of care in SMA. Biogen has also expanded its collaboration with Ionis to identify new gene therapies for the treatment of SMA as well as a broad range of neurological diseases. In...

    https://mschristian.org/index.php/blog/biogen-strengthens-ms-sma-portfolio-as-competition-lurks-yahoo-finance
  • Study sheds light on brain cell changes in people with MS

    arepresent in the brain from that person. The researchers found there are several types of oligodendrocytes, and that the ratio of these cells in people with MS differs from healthy people. These differences suggest the oligodendrocytes are functioning...

    https://mschristian.org/index.php/blog/study-sheds-light-on-brain-cell-changes-in-people-with-ms

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