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Reviewed by Emily Henderson, B.Sc.May 14 2020
In the brains of people that suffer from long-term Multiple Sclerosis (MS), inflammatory cells are not entering the brain via the bloodstream anymore. Instead, the cells arise from local memory cells in the brain. Nina Fransen and her colleagues of the Netherlands Institute for Neuroscience show this in a recently published article in the scientific journal Brain.
At its onset, MS is characterized by a relatively high frequency of attacks of neurological symptoms that recover relatively well. During attacks early in the disease, white blood cells migrate from the bloodstream into the brain, where they contribute to the inflammation. In patients with advanced MS, the number of attacks with neurological symptoms is reduced, but disability does progress.
Our previous studies indicated that there is still a significant amount of inflammatory activity in the brain also at later stages of MS, which is remarkable."
Nina Fransen, Netherlands Institute for Neuroscience